Menopausal Increases in Pulsatile Gonadotropin-Releasing Hormone Release in a Nonhuman Primate (Macaca mulatta)
نویسندگان
چکیده
منابع مشابه
Menopausal increases in pulsatile gonadotropin-releasing hormone release in a nonhuman primate (Macaca mulatta).
Reproductive function in all vertebrates is controlled by the circhoral release of the neuropeptide, GnRH, into the portal capillary system leading to the anterior pituitary. Despite its primary role in sexual maturation and the maintenance of adult reproductive function, changes in the concentrations and pattern of GnRH release have not yet been reported in any primate species during the menop...
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The major purpose of this study was to characterize the open-loop frequency of pulsatile GnRH release in the female rhesus monkey at an age (15-20 months) when the prepubertal restraint on the hypothalamic-pituitary axis is maximally imposed. Additionally, evidence for pulsatile GnRH release in agonadal males of comparable age was also sought. Episodic LH secretion from the pituitary was used a...
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Sexually mature gilts (n = 20) were actively immunized against GnRH. Primary and booster immunizations of GnRH conjugated to bovine serum albumin induced production of antibodies in all gilts. Nineteen of the gilts became acyclic with suppressed concentrations of gonadotropins and estradiol. Intravenous challenges with 100 micrograms GnRH and 5 micrograms D-(Ala6, des-Gly-NH2(10)) ethylamide Gn...
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Normal imaging of cerebrospinal fluid (CSF) flow in the primate Macaca mulatta 99m using Tc labeled human serum albumin shows flow from the basal cisterns over the cerebral cortex in 4 hours. Anatomical correlation of basal cisterns with cisternographic images was demonstrated with latex casts of the normal CSF spaces. Cisternographic images from nonhuman primates with experimental communicatin...
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There is growing evidence that alterations in the intrinsic circadian clock and sleep might affect the aging process. The rhesus monkey (Macaca mulatta) provides unique opportunities to explore the role of the clock in successful and unsuccessful physiological and cognitive aging in a diurnal primate with consolidated nighttime sleep, complex cognitive functions, long life span, and phylogeneti...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2004
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2004-0379